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In 1882, Annie Alexander, age seventeen, entered the Woman’s Medical College in Philadelphia. The Woman’s Hospital Dispensary for Women and Children was located next door to the Medical College. This provided many opportunities for the students to obtain clinical and practical experience. This training was essential if women physicians were to make any achievements in medicine.
Annie Lowrie Alexander was born on January 10, 1864 near the town of Cornelius in northern Mecklenburg County. Her parents were Dr. John Brevard Alexander and Annie Wall Lowrie Alexander. On her father's side, Annie’s ancestors were some of the county’s most illustrious leaders during the American Revolution.